Tel: (510) 642-1834
Fax: (510) 642-0535
Nutritional Sciences & Toxicology
119 Morgan Hall #3104
University of California
Berkeley, CA 94720-3104
We are utilizing systematic functional analysis through the use of “barcoding” analysis in the budding yeast Saccharomyces cerevisiae to identify genes involved in sensitivity and resistance to Superfund chemicals. We are currently focusing on metals, metalloids, and benzene and its metabolites, as well as emerging contaminants and pesticides. Our long term goal is identify conserved toxicity pathways that may influence susceptibility to toxicant exposure in eukaryotes, including people.
- North M, Vulpe CD. Functional Toxicogenomics: Mechanism-Centered Toxicology. Submitted to Int. J. Mol. Sci. 2010.
- Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe C, Chanock SJ, Smith MT, Lan Q. Systems biology of human benzene exposure. Chem Biol Interact. 2010 Mar 19;184(1-2):86-93. [PDF]
- Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame A, Smith MT, Vulpe CD, Zhang L. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):294-302. [PDF]
- Jo WJ, Loguinov A, Wintz H, Chang M, Smith AH, Kalman D, Zhang L, Smith MT, Vulpe CD. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci. 2009 Oct;111(2):424-36. [PDF]
- Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, Li G, Vulpe C, Lim S, Ren X, Rappaport SM, Berndt SI, Yeager M, Yuenger J, Hayes RB, Linet M, Yin S, Chanock S, Smith MT, Rothman N. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis. 2009 Jan;30(1):50-8. [PDF]
- Jo WJ, Kim JH, Oh E, Jaramillo D, Holman P, Loguinov AV, Arkin AP, Nislow C, Giaever G, Vulpe CD. Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae. BMC Genomics. 2009 Mar 25;10:130. [PDF]
- Jo WJ, Loguinov A, Chang M, Wintz H, Nislow C, Arkin AP, Giaever G, Vulpe CD. Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants. Toxicol Sci. 2008 Jan;101(1):140-51. Erratum in: Toxicol Sci. 2008 Mar;102(1):205. [PDF]