Publications

2025

Metayer C, Morimoto LM, Vieira VM, Godri Pollitt KJ, Bartell SM, Wong L, Young TM. Exposure to per- and polyfluoroalkyl substances in residential settled dust and risk of childhood acute lymphoblastic leukemia. Int J Cancer. PMID: 39950710. Former Project.

Rigutto G*, McHale CM, Rana I*, Zhang L, Smith MT. Mapping assays to the key characteristics of carcinogens to support decision-making. Database. 2025:baaf026. PMID: 40261741. PMCID: PMC12013474. Admin/Research Translation Core.

  • Key Characteristics Assay Database (KCAD) https://kcad.cchem.berkeley.edu/

Smith MT. The Key Characteristics Concept. March. Current Opinion in Toxicology. 41:100515. PMCID: PMC12017793. Admin/Research Translation Core.

Wang X, Charlie Zhong, Xiaomei Ma, Catherine Metayer, Nicolas Mancuso, W. James Gauderman, Joseph L. Wiemels. The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene–Environment Interaction Study. Cancer Epidemiol Biomarkers Prev. 34 (1): 100–107. PMID: 39495115. Former Project.

DeMarini DM, … Gabrielle Rigutto, … Aline de Conti, Mary K. Schubauer-Berigan, and Federica Madia. Commentary: IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards. 133(2) Feb 2025. 025001-1 to 025001-8. PMCID: 11790013

2024

Bozack AK*, Merrill SM, Cardenas A. Epigenetic Biomarkers for Understanding Adverse Experiences and Health. JAMA network open. 2024 August 1;7(8):e2427070. PMID: 39120907. Project 2

Estien CO, Christine E. Wilkinson, Rachel Morello-Frosch, and Christopher J. Schell. Historical Redlining Is Associated with Disparities in Environmental Quality across California. Environ Sci Technol. Lett. 2024 Jan 19;11(2):54-59. PMCID: PMC10867848. CEC/Project 1

Gao X, Mujahid MS, Nuru-Jeter AM, Morello-Frosch R. The Influence of Gentrification on Adverse Birth Outcomes in California. Journal of Urban Health: Bulletin of the New York Academy of Medicine. PMCID: PMC11652705. CEC/Project 1

Goin D*, Amy Padula, Allison Sherris, Kiley Charbonneau, Tracey Woodruff, Rachel Morello-Frosch. Water fluoridation and birth outcomes in California. Env Health Perspectives. PMCID: PMC11098007. CEC/Project 1

Karasaki S*, Arianna Libenson*, Tien Tran, Komal Bangia, Lara J. Cushing, Jenny L. Rempel, Laura August, Lauren Baehner, Morello-Frosch and Clare Pace. How a community-academic-government partnership for drinking water justice strengthens the rigor, relevance, reach, and reflexivity of science. Environmental Justice. doi: 10.1089/env.2024.0039. CEC/Project 1

Tae-Kyoung Kim*, Donghyun Lee, Griffin Walsh*, Changha Lee, David L. Sedlak. Unwanted Loss of Volatile Organic Compounds (VOCs) During in Situ Chemical Oxidation Sample Preservation: Mechanisms and Solutions. J Hazardous Materials Letters. 100102. PMCID: 11501080. Project 4

  • Dryad Temporary download link to raw data: http://datadryad.org/share/yHZI_c5xrxsvWMRkj2mWjzZ8bHQrYiKHlTmhejj5ruA.

La Merrill M, Martyn Smith, Cliona McHale, Jerry Heindel, Ella Atlas, Matt Cave, David Collier, Kathryn Guyton, Suneil Koliwad, Angel Nadal Navajas, Rob Sargis, Lauren Zeise and Bruce Blumberg. Consensus on the Key Characteristics of Metabolism Disruptors.  Nat Rev Endocrinol. 10/28/24. Administration Core. PMID: 39613954. PMCID: PMC11916920 (under embargo)

Libenson A*, Karasaki S*, Cushing LJ, Tran T, Rempel JL*, Morello-Frosch R, Pace C*. PFAS-Contaminated Pesticides Applied near Public Supply Wells Disproportionately Impact Communities of Color in California. Environmental Science and Technology, Water. PMCID: PMC11186009. CEC

  • Metadata: https://drinkingwatertool.communitywatercenter.org/wp-content/uploads/2025/01/pfas_pest_plss_metadata_100924.pdf
  • Shapefile: https://drinkingwatertool.communitywatercenter.org/wp-content/uploads/2025/01/pfas_pest_ai_plss_100924.zip

Liu, T, Keren Xu, Anmol Pardeshi, Swe Swe Myint, Alice Kang, Libby Morimoto, Michael Lieber, Joseph Wiemels, Scott Kogan, Catherine Metayer. Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia. Leukemia 2024 Nov;38(11):2492-2496. PMCID: PMC11518992. Former project

Madrigal JM, Gunier RB, Jones RR, Flory A, Metayer C, Nuckols JR, Ward MH. Residential proximity to agricultural herbicide and fungicide applications and dust levels in homes of California children. Environment international. PMID: 39326242; PMCID: PMC11610235. Former project

McCoy, D., Zhang, W., Hubbard, A., van der Laan, M., & Schuler, A. Data-Adaptive Identification of Subpopulations Vulnerable to Chemical Exposures using Stochastic Interventions. arXiv preprint arXiv:2406.10792.

  • Software package: https://github.com/blind-contours/EffectXshift.

McGachy L and Sedlak DL. Review. From Theory to Practice: Leveraging Chemical Principles To Improve the Performance of Peroxydisulfate-Based In Situ Chemical Oxidation of Organic Contaminants. Environ Sci Technol. PMCID: PMC10785823. Project 4

Perez-Garcia J, Cardenas A, Lorenzo-Diaz F, Pino-Yanes M. Precision medicine for asthma treatment: Unlocking the potential of the epigenome and microbiome. The Journal of allergy and clinical immunology. 2024 June 19. PMID: 38906272; PMCID: PMC12002393 (available on 2026-02-01). Project 2

Rempel JL and Kristin B Dobbin. When “symbolic” policy is anything but: Policy design and feedback from California’s human right to water law. Policy Studies Journal. https://doi.org/10.1111/psj.12564

Rempel, JL*, Belfer E*, Ray I, Morello-Frosch R. Access for Sale? Overlying Rights, Land Transactions, and Groundwater in California. Environmental Research Letters. 19(2):024017. PMCID: PMC10811753. CEC/Project 1

Smith Anna R*, Lin PD, Rifas-Shiman SL, Fleisch AF, Wright RO, Coull B, Finn PW, Oken E, Gold DR, Cardenas A. Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion. Environmental research. 2024 October 15;259:119555. PMID: 38964580; PMCID: PMC11365774 (available on 2025-10-15). Project 2

Suthar H, Tanghal RB, Chatzi L, Goodrich JA, Morello-Frosch R, Aung M. Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review. Current environmental health reports. 2024 September;11(3):404-415. PMCID: PMC11324697. CEC/Project 1

David Sedlak. Water For All. Global Solutions for A Changing Climate. 9780300256932. Published November 7, 2023, by Yale University Press.

2023

Aiken ML, Pace CE*, Ramachandran M, Schwabe KA, Ajami H, Link BG, Ying SC. Disparities in Drinking Water Manganese Concentrations in Domestic Wells and Community Water Systems in the Central Valley, CA, USA. Environ Sci Technol. 2023 Feb 7;57(5):1987-1996. Epub 2023 Jan 25. DOI: 10.1021/acs.est.2c08548. PMCID: PMC9910038.

  • Data in paper and a supplemental file called “es2c08548_si_001.pdf” which has multiple tables, figures and info. GUID: A4C5D083-6B10-43BF-82F6-8407F9FADBA9. Contact Samying@ucr.edu

Berberian Alique G., Jenny Rempel*, Nicholas Depsky, Komal Bangia, Sophia Wang and Lara J. Cushing. Racial/ethnic composition and the legacy of racism from historical redlining are significant predictors of drinking water contamination risks from oil and gas development in LA County. AJPH. 2023 Aug 31;e1-e10. doi: 10.2105/AJPH.2023.307374. Online ahead of print. PMCID: PMC10568503. CEC

  • Data in paper and SI.

Cardenas Andres, Raj P. Fadadu, Gerard H. Koppelman. Epigenome-wide association studies of allergic disease and the environment. J Allergy Clin Immunol. 2023 Sep;152(3):582-590.  doi: 10.1016/j.jaci.2023.05.020. PMID: 37295475. PMCID: PMC10564109 (available on 2024-09-01). Project 2

  • Data in paper and SI.

Cardenas Andres, Fadadu Raj, Bunyavanich Supinda. Climate change and epigenetic biomarkers in allergic and airway diseases. Journal of Allergy and Clinical Immunology. 152(5): 1060-1072. DOI https://doi.org/10.1016/j.jaci.2023.09.011. PMID: 37741554. PMCID: PMC10843253 (available on 2024-11-01). Project 2

  • Data in paper and SI. Supplementary Excel file Table E1 available at link: Data on epigenetic markers and/or associated gene annotations related to climate exposures were extracted from studies, when available

Cushing LJ, Babson Dobbin K, Osborne Jelks N, Liu X*, Morello-Frosch R. Water Insecurity and Population Health: Implications for Health Equity and Policy. Health Affairs. DOI: 10.1377/hpb20230921.68748. REPORT. CEC. https://www.healthaffairs.org/do/10.1377/hpb20230921.68748/full/

Duan Y*, Jiang W, and Sedlak DL. Surface Processes Control the Fate of Reactive Oxidants Generated by Electrochemical Activation of Hydrogen Peroxide on Stainless-Steel Electrodes. Environmental Science & Technology Article ASAP. DOI: 10.1021/acs.est.2c08404. https://pubs.acs.org/doi/full/10.1021/acs.est.2c08404 PMID: 36926844. PMCID: PMC10504418.

  • Data in paper and SI. Contact sedlak@berkeley.edu

Grigoryan H, Imani P*, Sacerdote C, Masala G, Grioni S, Tumino R, Chiodini P, Dudoit S, Vineis P, Rappaport SM. HSA Adductomics Reveals Sex Differences in NHL Incidence and Possible Involvement of Microbial Translocation. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 September 1;32(9):1217-1226. PubMed PMID: 37409972; PubMed Central PMCID: PMC10529301. Discontinued project 4 from prior segment.

  • Data Availability Statement. The data generated in this study are available upon request from the corresponding author.

Gushgari-Doyle Sara*, Christopher I. Olivares, Mohan Sun, and Lisa Alvarez-Cohen. Syntrophic Interactions Ameliorate Arsenic Inhibition of Solvent-echlorinating Dehalococcoides mccartyi. Environ. Sci. Technol.  57 (38): 14237–14247. PMID: 37695749. PMCID: PMC11055506. Project 3

Hejazi NS, Boileau P*, van der Laan MJ, Hubbard AE. A generalization of moderated statistics to data adaptive semiparametric estimation in high-dimensional biology. Statistical Methods in Medical Research. 2023 Mar;32(3):539-554. DOI: 10.1177/09622802221146313. PMID: 36573044. PMCID: PMC11078029

Jeon S, Ying Chu Lo, Libby M. Morimoto, Catherine Metayer, Xiaomei Ma, Joseph L. Wiemels, Adam J. de Smith, and Charleston W.K. Chiang. Evaluating genomic polygenic risk scores for childhood acute lymphoblastic leukemia in Latinos. medRxiv. 2023 Jun 12:2023.06.08.23291167. PMCID: PMC10312899.

  • Data in paper and SI..

Kim Tae-Kyoung* and David Sedlak. Mineralization of a Fully Halogenated Organic Compound by Persulfate under Conditions Relevant to in Situ Reduction and Oxidation: Reduction of Hexachloroethane by Ethanol Addition Followed by Oxidation. Environ.Sci Technol. PMCID: PMC10501115. Project 4

Lammers LN, Duan Y*, Anaya L, Koishi A, Lopez R, Delima R, Jassby D, and Sedlak DL. Electrolytic Sulfuric Acid Production with Carbon Mineralization for Permanent Carbon Dioxide Removal. ACS Sustainable Chem. Eng. 2023, 11, 12, 4800–4812. DOI: 10.1021/acssuschemeng.2c07441. PMCID: PMC10052359.

  • Data in paper and SI. Contact sedlak@berkeley.edu

Lupo Philip J. et al. Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium. Int J Cancer. 154(3):434-447. PMCID: PMC11034994

  • Data Availability Statement. Supporting data may be obtained by formal application to each of the participating Principal Investigators and the relevant ethical and regulatory bodies. Further information is available from the corresponding author upon request. Supplemental materials: NIHMS1981360-supplement-Supinfo.pdf.

Madrigal JM, Gunier RB, Jones RR, Flory A, Metayer C, Nuckols JR, Ward MH. Contributions of nearby agricultural insecticide applications to indoor residential exposures. Environment international. 2023 January;171:107657. PMCID: PMC10038187; DOI: 10.1016/j.envint.2022.107657.

McCoy D*, Hubbard A, and van der laan M. CVtreeMLE: Efficient Estimation of Mixed Exposures using Data Adaptive Decision Trees and Cross-Validated Targeted Maximum Likelihood Estimation in R. Journal of Open Source Software. Published Feb 21, 2023. DOI: 10.21105/joss.04181. PMCID: PMC10312067. DMAC.

McCoy David*, Alejandro Schuler, Alan Hubbard, and Mark van der laan. SuperNOVA: Semi-Parametric Identification and Estimation of Interaction and Effect Modification in Mixed Exposures using Stochastic Interventions in R.  Journal of Open Source Software. 8(91): 5422. PMCID: PMC11087079. SOFTWARE PACKAGE. DMAC

Metayer Catherine, Libby M Morimoto, Alice Y Kang, Jacklyn Sanchez Alvarez, Lena E Winestone. Pre- and post-natal exposures to tobacco smoking and survival of childhood acute lymphoblastic and myeloid leukemias in California, United States. Cancer Epidemiol Biomarkers Prev. 2023 Nov 3. doi: 10.1158/1055-9965.EPI-23-0801. Online ahead of print. PMID: 37921440. PMCID: PMC11008006 (available 2024, July)

Rempel, J*., Fencl, A., and Community Water Center. The Rural Water Gap: A Retrospective Equity Analysis of USDA Rural Development’s Water and Environmental Program. Community Water Center. Sacramento, CA. Report URL. CEC.

Woodruff TW, Rayasam SDG, Axelrad DA, Koman PD, Chartres N, Bennett DH, Birnbaum LS, Brown P, Carignan CC, Cooper C, Cranor CF, Diamond ML, Franjevic S, Gartner EC, Hattis D, Hauser R, Heiger-Bernays W, Joglekar R, Lam J, Levy JI, MacRoy PM, Maffini MV, Marquez EC, Morello-Frosch R, Nachman KE, Nielsen GH, Oksas C, Abrahamsson DP, Patisaul HB, Patton S, Robinson JF, Rodgers KM, Rossi MS, Rudel RA, Sass JB, Sathyanarayana S, Schettler T, Shaffer RM, Shamasunder B, Shepard PM, Shrader-Frechette K, Solomon GM, Subra WA, Vandenberg LN, Varshavsky JR, White RF, Zarker K, Zeise L. A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement. Environ Health. 2023 Jan 12;21(Suppl 1):132.  doi: 10.1186/s12940-022-00930-3. PMCID: PMC9835243.

  • Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

Zhang L, Louie A*, Rigutto G*, Guo H*, Zhao Y*, Ahn S, Dahlberg S*, Sholinbeck M, Smith MT. A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure. Environ Res 2023 Mar 1;220:115188. doi: 10.1016/j.envres.2022.115188. PMID: 36592815.

  • Data in paper (6 tables and 6 figures) and supplemental file called “1-s2.0-S0013935122025154-mmc1” of type multimedia component 1” which has 11 supplementary tables in Word format. Contact luoping@berkeley.edu