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From Free Radicals to Key Characteristics

Celebrating Research to Action – Past, Present, and Future

Description: In the morning, we will celebrate the seventh successful renewal of the Berkeley Superfund Research Center, and forty years of the Smith Lab with talks and comments by distinguished alumni. In the afternoon, we will celebrate ten years of the “Key Characteristics” and imagine future applications.

Host: Martyn Smith, Director, UC Berkeley Superfund Research Program. With Office of Environmental Health Hazard Assessment, California EPA.

Venue: David Brower Center, 2150 Allston Way, Berkeley, CA 94704. View Map

Date: June 10, 2022. Program 9am – 5pm. Reception 5-7pm.

Registration: Opens May 12. Fee includes lunch and reception.


Students and Postdoctoral Fellows
$25 online

General Attendees
$50 online

*Registration is limited by the venue’s capacity; please register early.



The meeting will be held at the:

David Brower Center
2150 Allston Way (between Shattuck Avenue and Oxford Street)
Berkeley, CA



The David Brower Center is located approximately a 6-minute walk from the Downtown Berkeley BART station. Head south on Shattuck Avenue (towards Oakland) and turn east (towards the campus) at the first intersection, Allston Way.



The City of Berkeley Oxford Garage is located under the Brower Center. The garage entrance is at:

2165 Kittredge Avenue (between Shattuck Avenue and Oxford Street). Parking rates for this garage can be found here.

Information for other City of Berkeley garages and off-street parking can be found here.



The nearest hotels are:

Hotel Shattuck Plaza
2086 Allston Way (at Shattuck Avenue)
Berkeley, CA 94704

Residence Inn by Marriott
2121 Center Street
Berkeley, CA 94704

Graduate Berkeley (Government rate available)
2600 Durant Ave
Berkeley, CA 94704



If you have questions or require an accommodation for effective communication (ASL interpreting/CART captioning, alternative media formats, etc.) to fully participate in this event, please contact Dr. Cliona McHale at or (510) 643-5100 with as much advance notice as possible and at least 7-10 days in advance of the event.


Morning Sessions:

Session 1: Celebrating the ~7th Successful Renewal of the NIEHS Superfund Research Center – Alan Hubbard, Professor of Biostatistics (Chair)

9.00 Introduction and opening remarks – Martyn Smith, Director Superfund Research Center; Michael Lu, Dean BPH; Catherine Koshland*, Vice-Chancellor and Provost; William Suk*, Director, NIEHS Superfund Research Program; Robert Spear, Emeritus Professor and Former Director of COEH.

9.15 New Projects and Cores – Professors Rachel Morello-Frosch; Joseph Lewnard; David Sedlak; Lisa Alvarez-Cohen; Alan Hubbard (UC Berkeley)

Session 2: Celebrating 40 years of the Smith Lab with talks and comments by distinguished alumni – Professors David Ross (U.Colorado) and David Eastmond (UC Riverside) (Co-Chairs)

10.00 “MPTP, Paraquat and Parkinson’s Disease” – Prof. Dr. Donato Di Monte*(German Center for Neurodegenerative Diseases); Comments by 1980s alumni including Drs. Martha Sandy, Gunilla Ekstrom* and Sarah Jewell*

10.25 Break

10.40 “Benzene, NQO1 and Bone Marrow Toxicity” – Professors David Ross and David Eastmond with comments from collaborators Drs. Nat Rothman*(NCI), Qing Lan*(NCI), and 1990s alumni

11.05 “Childhood Cancer” – Professor Joseph Wiemels (USC) with comments from Dr. Cliona McHale and 2000s alumni

11.30 “Exposomics” – Professor Rosemarie de la Rosa (UC Berkeley); with comments from 2010s alumni including Prof. Fenna Sille*(Johns Hopkins), Dr. Sylvia Sanchez* (Johns Hopkins) and others

11.55 Summary and wrap up – Professor Emeritus Stephen Rappaport (UC Berkeley)

12.00 Lunch (provided)

Afternoon Sessions

Session 3: Celebrating 10 years of the Key Characteristics (KCs) – Dr. Vincent Cogliano (Deputy Director for Scientific Programs at OEHHA) (Chair)

1.00 “Introduction and the Birth of the KCs” – Dr. Vincent Cogliano (OEHHA)

1.10 “10 years of the KCs of carcinogens” – Dr. Kathryn Guyton (National Academies)

1.30 “IARCs experience with the KCs” – Recorded video from Dr. Mary Schubauer-Berigan (Head of the IARC Monographs Programme)

1.40 “NAMs and In Silico approaches to the KCs” – Dr. Raymond Tice*(RTice Consulting); Prof. David Reif (N. Carolina State U.); Dr. Kamel Mansouri (NTP), Dr. Vangala Subrahmanyam (Reagene)

2.35 Break

Session 4: Imagining the Future of the KCs – Professor Michele La Merrill (UC Davis) (Chair)

2.50 “New sets of KCs and their potential application” – Hepatotoxicants – Prof. Ivan Rusyn (Texas A&M); Immunotoxicants – Dr. Dori Germolec (NIEHS); EDCs/Metabolic disruptors – Prof. Michele La Merrill (UC Davis)

3.35 Break
3.50 “Applying the KCs in decision making” – Dr. Martha Sandy (Chief, Reproductive and

Cancer Hazard Assessment Branch, OEHHA); Xabier Arzuaga (US EPA), Amy Wang (NIEHS)
4.35 “Panel discussion on future applications of the KCs” led by Professor Emeritus Amy Kyle

(UC Berkeley) with Prof. Tracey Woodruff (UCSF) and Dr. Kathleen Durkin (UC Berkeley) 4.50 Future directions for the KCs: Dr. Lauren Zeise (Director, OEHHA)
5.00 Reception
7.0 Close

*Via Zoom

Join the meeting on Zoom by registering at